Pharmaceutical interests in the UK are
ignoring new scientific research that shows the
insecticide used in the UK government's own warble-fly
campaigns triggered the UK surge of 'Mad Cow' disease.
Latest experiments by Cambridge University prion
specialist, David R. Brown, have shown that manganese
bonds with prions. Other researchers work shows that
prions in the bovine spine -- along which insecticides
are applied -- can be damaged by ICI's Phosmet
organophosphate(OP) insecticide -causing the disease.
British scientists have led the current theory that an
infectious prion in bonemeal fed to cattle causes bovine
spongiform disease (BSE).
Infectious prions are also claimed to cause new variant
Creutzfeld-Jakob Disease (CJD) in humans -from ingesting
beef. But the infectious prion theory serves to obscure
a tragic chemical poisoning scandal behind the majority
of BSE cases.
The new work proves that the prions can bond with
manganese in animal feeds or mineral licks. These
manganese prions cause the neurological degeneration
seen in BSE. By a similar process, prions in human
brains are damaged by lice lotions containing
organophosphate. This can result in neurological
diseases like CJD and Alzheimer's -later in life.
Many might be surprised to hear that organophosphates
were developed by Nazi chemists during the course World
War Two, as a chemical weapon nerve agent. One
formulation of the insecticide -- Maneb, or Mancozeb --
actually contains manganese in addition to
organophosphate.
The marginalized research has devastating financial
implications for ICI. It would provide a firm basis for
litigants -who could include CJD sufferers, farmers
across the world and families of the many British
farmers who committed suicide during this BSE debacle.
Phosmet organophosphate has been used at high doses in
British warble fly campaigns. In 1996, ICI subsidiary
Zeneca sold the phosmet patent to a PO Box company in
Arizona called Gowan -just one week before the UK
government admitted to a link between BSE and nvCJD.
The politically well-connected British pharmaceuticals
group, ICI has the financial and political clout to
block research into any cause other than the infective
model. Indeed no substantive alternative research has
been done. British BSE disease management and research
bodies have taken decisions that do not seem guided by
spirited scientific enquiry. Mysterious prions that jump
species is the preferred research arena.
Scientist and organic farmer, Mark Purdey gave evidence
to the UK BSE inquiry, that warble fly insecticide was
the cause of the disease. The scientist wheeled out to
rubbish Purdy's evidence -Dr. David Ray, later turned
out to have been receiving funding from the insecticide
manufacturer ICI.
A lobby group that includes Bayer, Monsanto, Novartis,
Pfizer, Roche and Schering-Plough was behind the effort
to discredit Purdey. In December 1999, the same David
Ray was appointed to the UK Veterinary Products
Committee (VPC) -a government body that licences animal
medicines.
Purdey has been consistently denied even exploratory
funding to extend his privately supported research. Yet
the Purdey/Brown chemical poisoning model matches with
the epidermiological spread of CJD clusters in humans.
It also predicts the incidence of BSE-type diseases in
animals. The accepted infectious model fits neither.
The pharmaceutical industry is all the more determined
to hide the chemical source of BSE and CJD, because a
spotlight on chemicals would expose the role the
insecticides in Alzheimer's -- another neurodegenerative
disease -- that might lead to claims which would dwarf
those from BSE and CJD litigants. In fact, two leading
brain researchers into CJD and Alzheimer's have died in
suspicious circumstances in recent years.
In the United States, the Environmental Protection
Agency is already reviewing Phosmet's safety. The
Centers for Disease Control in the US has recently
conducted experiments on mice that confirm the
organophosphate risk.
Not only is the EC beef slaughter campaign futile
-because BSE disease is mostly non-infectious, but
unless the underlying chemical cause is addressed, BSE
will simply reappear from chemical causes. A new warble
fly campaign is already underway in France using the
organophosphate insecticide.
Of greater concern is that some lotions for scabies and
head lice are now priming children and adults, for CJD
and Alzheimer's in later life.
Bonding The Prion
Cambridge University prion biochemist, David R. Brown is
dismissive of the science behind the infectious model of
BSE. He terms it "a very limited amount of science by a
few assumed- reputable scientists." He insists there is
"no evidence an infectious agent is present in either
meat or milk."
"Simple tests on udder walls of cows -- which could
easily detect an infectious prion -- have not been done,
why I don't understand."
A number of researchers have found that organophosphate
(OP) in systemic warble fly insecticide can deform the
prion molecule, rendering it ineffective at buffering
free radical effects in the body. Worse still, the prion
is then partial to bond with manganese and become a
'rogue' prion. A chain reaction whereby rogue prions
turn others to rogues also, can explain the bovine
spongiform disease mechanism.
Brown showed how prion protein bonds benignly with
copper, but lethally with manganese. Even natural
variations in relative environmental availability of
manganese versus copper can trigger prion degradation.
The CJD and BSE symptoms mirror 'manganese madness', an
irreversible fatal neuro-psychiatric degenerative
syndrome that plagued manganese miners in the first half
of the last century Shining a
Light on Spongiform
Organic dairy farmer and peer-review-published
independent scientist, Mark Purdey, says the accepted
theory of transmission from BSE-infected cattle to human
CJD -by bonemeal or meat, is dependent on a mutant prion
that has never been isolated under the scientific
protocol called Koch's postulates.
Purdey's insistence on sticking to the letter of this
scientific law earned him the condemnation of UK
officialdom when he first mooted his theory. But Purdey
pointed to CJD clusters downwind of a British Phosmet
production plant to back his case.
He gave evidence to the UK Government BSE inquiry and
was supported by Conservative MP, Thessa Gorman. His
views were discounted, but his subsequent research and
the new Cambridge prion work have confirmed the
alternative theory. Despite this, and the backing of a
British peer, he is denied even exploratory funding.
Speaking from his rural English Somerset farm yesterday
-as plans forge ahead for the European cattle cull, he
asks:
"Why does CJD degeneration in humans begin in the
retina, and why are CJD disease clusters found in high
altitude locations?"
The question is rhetorical, and Purdey has an
eye-opening answer. He argues that the prion molecule
has a known natural role as a shock adsorber of damaging
energy from ultraviolet rays and other oxidizing agents.
Once this prion defense system is rendered ineffective
by organophosphates - for example in human head lice
lotions, these oxidizing effects have an unmediated
impact on tissues. Eventually, UV radiation damages the
retina and oxidative stress destroys the brain tissues
of CJD patients. This theory would expect to find higher
CJD incidence in mountain regions -where UV radiation
levels are elevated. That prediction holds true.
A similar but accelerated mechanism could be driving BSE.
ICI's Phosmet organophosphate warble fly insecticide
-applied on the backs of animals along the spinal
column, similarly degrades prions. "Systemic versions of
the insecticide are designed to make the entire cow
carcass toxic to warble fly," explains Purdey.
"Unfortunately it's toxic to prions too -especially
those prions located just millimeters from the point of
application."
The damaged prions are then ready to react with
manganese in animal feed, or manganese sprayed on land
or in mineral licks -to become the driving force of BSE
neurodegeneration. Purdey says manganese-tipped prions
set off lethal chain reactions that neurologically burn
through the animal.
Chickens notoriously excrete most of the supplements fed
to them -including manganese. And their manganese-rich
excreta have been blended into cattle feed in the UK.
Natural variations in the relative environmental
availability of copper and manganese can also spur prion
degeneration says Purdey.
From this research, any prudent person would conclude
there is a significant risk attaching to the use of
organophosphate in humans. Preparations for head lice
and scabies are known to be overused in practice and
might be priming users for CJ disease.
Purdey believes his bias for field work is the key to
his success. He bemoans the "reductionism" of much
lab-centered science. "I have traveled the world to
investigate known clusters of spongiform disease
-something mainstream researchers don't seem remotely
interested in doing."
Since first postulating an environmental -rather than
infectious- theory of spongiform diseases, Purdey has
built evidence from around the world that explains and
predicts the incidence in humans and animals: a cluster
of CJD in Slovakia, Eastern Europe -around a manganese
plant; Rocky Mountain deer with Chronic Wasting Disease
(CWD), who were found to be eating pine needles rich in
manganese; the futile slaughter of sheep in Cyprus -only
for BSE to reemerge within years.
"The reappearance of BSE in Cyprus obviously points to
an environmental cause," says Purdey, who is sanguine
when reflecting on the condemnation of him by mainstream
scientists.
"I suppose they have mortgages and kids who need to go
to university," he muses. "Privately, some were agreeing
with me, but then they would denounce me publicly. It
was quite strange really."
The Money Trail
Critical scientists like Purdey are unlikely to prevail.
The pharmaceutical industry holds most research purse
strings, and would hardly energetically explore an
avenue of research that could expose them to litigation
for causing BSE. The official theory is lavishly funded,
alternative theories rarely, if at all.
There are more explosive implications to his -and
other's latest research. Purdey says similar
organophosphate-induced protein deformation could also
underlie Alzheimer's disease. If that were true, the
litigation fallout would destroy some pharmaceutical
giants, and a lot of very influential noses would be out
of joint.
Disturbingly, Purdey and other brain researchers seem to
have had an undue share of unfortunate accidents.
Purdey's house was burned down and his lawyer who was
working with him on Mad Cow Disease was driven off the
road by another vehicle and subsequently died. The
veterinarian on the case also died in a car crash
-locally reported as: 'Mystery Vet Death Riddle.'
Dr. C. Bruton, a CJD specialist -- who had just produced
a paper on a new strain of CJD -- was killed in a car
crash before his work was announced to the public.
Purdey speculates that Bruton might have known more than
what was revealed in his last scientific paper.
In 1996, leading Alzheimer's researcher Tsunao Saitoh,
46 and his 13-year-old daughter were killed in La Jolla,
California, in what a Reuters report described as a
"very professionally done" shooting.
What Alzheimer's Disease, Mad Cow Disease, and CJ
Disease have in common, is abnormal brain proteins and a
putative link to organophosphates. Even Gulf War
syndrome among returning veterans has been attributed,
in part to the insecticide. But the sidelined
scientists' suspicions are still largely ignored.
In their favor at the moment, is a growing unease on the
part of the public. As BSE forges on and Governments
panic, Science may be out to lunch on BSE, compromised
by bovine spongythinking myopathy.
- Do NOT use Systemic Organophosphate
Insecticides
- Do NOT treat children with OP head
lice products - they may cause CJD and Alzheimer's
- Do NOT treat your pets with OP
anti-flea products
- Do NOT treat cattle or animals with
OP products - they may cause BSE
- Do NOT give manganese to cattle
previously dosed with a systemic OP
- The relative availability of the
metals copper and manganese in you local environment
is a major factor in BSE & CJD
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